Researchers used tiny, magnetic spheres to deliver a gene editing toolbox into stem cells prepared from a patient’s skin sample and correct a genetic mutation known to cause Rett syndrome. When the edited stem cells were given cues to turn into neurons (nerve cells) in the lab, they looked…
Treatment with ADH-503, an experimental oral treatment for pancreatic cancer, was found to slow disease progression and prolong survival in a mouse model of Rett syndrome, according to a study that focused on how brain immune cells may play a role in Rett. “I hope this work will ‘move…
Neurons activated at the same time — a state called neuronal synchrony — and with lesser complexity in the relationships between nerve cells of the brain and the body may contribute to the aimless and repetitive movements of Rett syndrome, a recent animal study suggests. The study, “Collapse of…
Exosomes — small vesicles released by cells that play an important role in cell communication — carry chemical signals that help regulate the function and development of neural circuits and may even reverse some of the abnormal features observed in a cellular model of Rett syndrome, a study has…
A study in rats has provided new clues as to how the brain works to control body movements, which may have implications for disorders such as Rett syndrome. The study, “Strong neuron-to-body coupling implies weak neuron-to-neuron coupling in motor cortex,” was published in the journal Nature…
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