Author Archives: Patricia Inacio PhD

Disease Severity Tied to Two Neuroprostanes

Elevated levels of two neuroprostanes — markers of oxidative stress, a result of insufficient antioxidant defenses against toxic free radicals — are linked with symptom severity and type of mutations in people with Rett syndrome, a study reports. These findings support the potential of the neuroprostanes as biomarkers to…

LAVENDER Phase 3 Trial of Trofinetide Enrolling at New Sites

Acadia Pharmaceuticals is enrolling participants at four new clinical sites in its Phase 3 LAVENDER trial testing trofinetide as a treatment for girls and young women with Rett syndrome. In an online letter to the Rett community, Acadia announced these recent additions: Seattle Children’s Hospital; the University of North Carolina…

COVID-19 Economic Stimulus Legislation Welcomed by The Arc

The Arc and its advocates are welcoming the U.S. Congress’ decision to pass COVID-19-related economic stimulus legislation, which will extend access to Medicaid home and community-based services (HCBS) for people with intellectual and developmental disabilities (IDD). The $1.9 trillion American Rescue Plan Act of 2021, passed Tuesday and signed…

Taysha, Yale to Advance Gene Therapy Program

Note: This story was updated April 22, 2021, to clarify the collaboration between Yale and Taysha at the company’s request.  Taysha Gene Therapies has established a new research partnership with Yale University to advance its gene therapy program for neurodevelopmental disorders, which includes Rett syndrome, the company announced.

Teeth Grinding Is Most Common Dental Problem

Bruxism, also known as teeth grinding and jaw clenching, is the most common oral manifestation in patients with Rett syndrome, according to a small review of literature. The study, “Oral Manifestations of Rett Syndrome—A Systematic Review,” was published in the International Journal of Environmental Research and Public…