A molecular sensor of infections called the NLRP3 inflammasome is overactive in immune cells of people with Rett syndrome, a new study reveals. The study, “The constitutive activation of TLR4-IRAK1- NFκB axis is involved in the early NLRP3 inflammasome response in peripheral blood mononuclear cells of…
To support scientific investigations that seek therapies and a cure for Rett syndrome, the International Rett Syndrome Foundation (IRSF) is investing $2.3 million in research grants. The IRSF worked with its scientific advisory board (SAB) to determine the studies to advance. To develop treatments for the rare…
In people with Rett syndrome, cells known as fibroblasts have a distinct protein production profile — called a proteome — that overrepresents biological pathways related to immune function and inflammation, a small study reports. These findings may help researchers better…
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