Michela Luciano, PhD,  Science Writer—

Researchers in Italy described a rare case of 27-year-old identical twin sisters with Rett syndrome who, despite sharing the same disease-causing mutation, developed symptoms of different severity. Identical (monozygotic) twins develop from a single fertilized egg that divides into two embryos, so they are genetically identical. “The clinical differences…

Taysha Gene Therapies has reached an agreement with the U.S. Food and Drug Administration (FDA) on the design and next steps to start the pivotal Part B of its ongoing Phase 1/2 REVEAL trial program, which is evaluating TSHA-102 in children, adolescents, and adults with Rett syndrome.