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Reduced orexin signaling may cause Rett syndrome sleep problems

Reduced production of orexin and its receptors is associated with problems in sleep-wake cycles in a mouse model of Rett syndrome (RTT), a study suggests. Orexin is a signaling molecule that regulates sleep and wakefulness in the brain. While circadian rhythms that regulate the sleep-wake cycle were generally unaffected in…

Cannabis-based oil eases symptoms in Rett syndrome girls

NTI164, a cannabis-based oil being developed by Neurotech International, may help girls with Rett syndrome communicate more easily, enjoy better moods, and have a better quality of life with few side effects, a small study in Australia found. The study, “Full-Spectrum Medicinal Cannabis Plant Extract 0.08% THC (NTI164)…

Different types of motor disorders often co-occur in Rett syndrome

Many types of movement disorders such as uncontrolled muscle contractions and Parkinson’s-like motor changes often co-occur with Rett syndrome, a study shows. The severity of movement disorders is associated with Rett’s overall severity, with uncontrolled muscle contractions particularly linked with breathing trouble and digestive problems, data indicate. The findings…